It mostly takes the form of an IgM antibody (the largest antibody type) and specifically targets a region on IgG antibodies. The rheumatoid factor is a curious autoantibody that attacks other antibodies. Detectable levels of the rheumatoid factor were uncovered in people with other autoimmune diseases, chronic infections, cancer, liver disease, and parasites. Since then, it became evident that other conditions can also trigger its production. ![]() This marker got its name from its initial discovery in people with rheumatoid arthritis. Autoantibodies trigger autoimmunity and inflammation responses by mistakenly mounting an attack against the body’s own tissues. Rheumatoid factor (RF) is an autoantibody produced by the immune system. We break down all the possible causes and effects of high levels. Although useful in diagnosing rheumatoid arthritis and monitoring disease activity, this marker may also be produced in other inflammatory diseases and certain infections. Rheumatoid factor is an antibody that usually signals an autoimmune attack in the body. A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at that each number in parentheses is a clickable link to peer-reviewed scientific studies. Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. ![]() Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. ![]() We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed.
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